Receptor-mediated delivery of siRNAs by tethered nucleic acid base-paired interactions
نویسندگان
چکیده
منابع مشابه
Ion-mediated nucleic acid helix-helix interactions.
Salt ions are essential for the folding of nucleic acids. We use the tightly bound ion (TBI) model, which can account for the correlations and fluctuations for the ions bound to the nucleic acids, to investigate the electrostatic free-energy landscape for two parallel nucleic acid helices in the solution of added salt. The theory is based on realistic atomic structures of the helices. In monova...
متن کاملMetal-mediated base pairing within the simplified nucleic acid GNA.
Hydroxypyridone and pyridopurine homo- and hetero-base pairs have been investigated in the context of duplex GNA (glycol nucleic acid). Phosphoramidites for automated GNA solid phase synthesis were synthesized economically in a few steps starting from commercially available enantiopure glycidol. Similar to their behavior in DNA, the hydroxypyridone and pyridopurine homo-base pairs display a met...
متن کاملSurface- and hydrogel-mediated delivery of nucleic acid nanoparticles.
Gene expression within a cell population can be directly altered through gene delivery approaches. Traditionally for nonviral delivery, plasmids or siRNA molecules, encoding or targeting the gene of interest, are packaged within nanoparticles. These nanoparticles are then delivered to the media surrounding cells seeded onto tissue culture plastic; this technique is termed bolus delivery. Althou...
متن کاملFluorescent nucleic acid base analogues.
The use of fluorescent nucleic acid base analogues is becoming increasingly important in the fields of biology, biochemistry and biophysical chemistry as well as in the field of DNA nanotechnology. The advantage of being able to incorporate a fluorescent probe molecule close to the site of examination in the nucleic acid-containing system of interest with merely a minimal perturbation to the na...
متن کاملAcid-base Interactions 10.1 GENERAL CONCEPT OF ACID-BASE INTERACTIONS
Acid-base interactions have found numerous applications in research dealing with adsorption of molecules of liquids on the surfaces of solids. The main focus of this research is to estimate the thermodynamic work of adhesion, determine mechanism of interactions, analyze the morphology of interfaces and various surface coatings, develop surface modifiers, study the aggregation of macromolecular ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: RNA
سال: 2008
ISSN: 1355-8382
DOI: 10.1261/rna.739308